中文名 | N-辛酰基-D-神经鞘氨醇 |
英文名 | C8 Ceramide |
别名 | C-8神经酰胺 N-辛酰基鞘氨醇 N-辛酰神经鞘氨醇 N-辛酰基-D-神经鞘氨醇 N-辛酰基-D-赤型鞘氨醇 N-[(1S,2R,3E)-2-羟基-1-(羟甲基)-3-十七碳烯-1-基]-辛酰胺 N-[(1S,2R,3E)-2-羟基-1-(羟基甲基)-3-十七碳烯-1-基]-辛酰胺 |
英文别名 | C8 CERAMIDE C8 Ceramide N-Octanoyl-D-erythr N-OCTANOYLSPHINGOSINE N-OCTANOYL-D-SPHINGOSINE N-Octanoyl-C18-sphingosine D-erythro-N-Octanoylsphingosine N-OCTANOYL-D-ERYTHRO-SPHINGOSINE N-OCTANOYLSPHINGOSINE, D-ERYTHRO N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]Octanamide |
CAS | 74713-59-0 |
化学式 | C26H51NO3 |
分子量 | 425.69 |
密度 | 0.9974 (rough estimate) |
熔点 | 68-70°C |
沸点 | 541.37°C (rough estimate) |
溶解度 | DMSO或乙醇: 可溶性 |
折射率 | 1.6000 (estimate) |
存储条件 | −20°C |
稳定性 | 温度敏感 |
外观 | 蜡状固体 |
颜色 | White |
体外研究 | C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes. C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells. C8-ceramide may increase the endogenous ROS level (10-30 µM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 µM; 24 hours), and consequently triggering the apoptosis (10-50 µM; 48 hours) of NSCLC H1299 cells. Cell Viability Assay Cell Line: CALO cells, INBL cells, HeLa cells Concentration: 3 μM Incubation Time: 48 hours Result: Markedly reduced the tumor cell number. Cell Proliferation Assay Cell Line: H1299 cells Concentration: 10 µM, 20 µM, 30 µM, 40 µM, 50 µM Incubation Time: 24 hours Result: Decreased the rate of cellular proliferation in a dose-dependent manner, with an IC 50 of 22.9 µM. Cell Cycle Analysis Cell Line: H1299 cells Concentration: 10 µM, 20 µM, 30 µM, 40 µM, 50 µM Incubation Time: 24 hours Result: Caused the G1 arrest. Apoptosis Analysis Cell Line: H1299 cells Concentration: 10 µM, 20 µM, 30 µM Incubation Time: 24 hours, 48 hours Result: Increased the level of cleaved caspase-3. |
体内研究 | C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8 + and CD4 + T cell responses to viral infections in virus infected mice. Animal Model: C57BL/6 mice, with lymphocytic choriomeningitis virus infected Dosage: 0.1 mg/kg Administration: Intranasal administration Result: Increased the CD8 + T cell response to influenza in the lungs. |
安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
海关编号 | 29225000 |
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